Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31081342 | 1.00 | KDM5B (0.47) | KDM5BKDM5AKDM4CLDHANOX4 | |
| SCHEMBL175148 | 0.81 | NOX4 (0.35) | KDM5BKDM5AKDM4CLDHANOX4 | |
| SCHEMBL17290637 | 0.81 | RAB9A (0.49) | POLBMAPTHPGDSMN1; SMN2NPSR1 | |
| SCHEMBL17291030 | 0.79 | HSD11B1 (0.45) | — | |
| SCHEMBL17290488 | 0.77 | MPO (0.50) | PTPRCPTPN1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL4309468 | 0.74 | MEN1 (0.58) | LDHANOX4ADORA2AADORA1POLB | |
| SCHEMBL5394842 | 0.71 | MAPT (0.52) | LDHAADORA2AADORA1POLBMAPT | |
| SCHEMBL7167710 | 0.71 | GRIN2D (0.34) | NOX4POLBMAPTHPGD | |
| SCHEMBL23402302 | 0.68 | LDHA (0.48) | KDM5BLDHANOX4POLBMAPT | |
| SCHEMBL2197780 | 0.67 | KDM5B (0.43) | KDM5BKDM5AKDM4CLDHAADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0663395-B1 | 3-(phenylalkylaminoalkyloxy)-5-phenylpyrazole derivatives, process and intermediates for their preparation and their use as cardiac rhythm reduction agent | SOLVAY PHARM GMBH (DE) | 2001-05-16 | — | — | EP | disclosed |
| US-5679699-A | ANTIISCHEMIC AGENTS, HEART RATE LOWERING AGENTS | KALI-CHEMIE PHARMA GMBH (DE) | 1997-10-21 | — | — | US | disclosed |
| US-5547967-A | HYPOTENSIVE AGENT, ANTIISCHEMIC AGENT | KALI-CHEMIE PHARMA GMBH (DE) | 1996-08-20 | — | — | US | disclosed |
| EP-0663395-A1 | 3-(phenylalkylaminoalkyloxy)-5-phenylpyrazole derivatives, process and intermediates for their preparation and their use as cardiac rhythm reduction agent | Kali-Chemie Pharma GmbH (DE) | 1995-07-19 | — | — | EP | disclosed |