Sugi Predict

Sugi Predict / Compounds / SCHEMBL7811091

SCHEMBL7811091

SCHEMBL7811091

CCCCCCCn1cncn1

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ TBXAS1 P24557 1/20 0.46
▸ EGLN3 Q9H6Z9 1/20 0.46
▸ MEN1 O00255 3/20 0.45
▸ KMT2A Q03164 3/20 0.45
▸ TLR8 Q9NR97 1/20 0.45
▸ TLR7 Q9NYK1 1/20 0.45
▸ MAPK1 P28482 1/20 0.44
▸ KDM4E B2RXH2 2/20 0.41
▸ MAPT P10636 2/20 0.41
▸ LMNA P02545 1/20 0.41
▸ GAA P10253 1/20 0.41
▸ USP2 O75604 1/20 0.41
▸ TSHR P16473 1/20 0.41
▸ HSD17B10 Q99714 1/20 0.41
▸ ALDH1A1 P00352 1/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11469362 1.00 TBXAS1 (0.46) TBXAS1EGLN3MEN1KMT2ATLR8
SCHEMBL11479558 1.00 TBXAS1 (0.46) TBXAS1EGLN3MEN1KMT2ATLR8
SCHEMBL11471344 1.00 TBXAS1 (0.46) TBXAS1EGLN3MEN1KMT2ATLR8
SCHEMBL11472749 1.00 TBXAS1 (0.46) TBXAS1EGLN3MEN1KMT2ATLR8
SCHEMBL11471431 1.00 TBXAS1 (0.46) TBXAS1EGLN3MEN1KMT2ATLR8
SCHEMBL8464105 1.00 TBXAS1 (0.46) TBXAS1EGLN3MEN1KMT2ATLR8
SCHEMBL11471409 1.00 TBXAS1 (0.46) TBXAS1EGLN3MEN1KMT2ATLR8
SCHEMBL11485316 1.00 TBXAS1 (0.46) TBXAS1EGLN3MEN1KMT2ATLR8
SCHEMBL11488575 1.00 TBXAS1 (0.46) TBXAS1EGLN3MEN1KMT2ATLR8
SCHEMBL11479603 1.00 TBXAS1 (0.46) TBXAS1EGLN3MEN1KMT2ATLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4160838-A FUNGICIDES, BACTERICIDES JANSSEN PHARMACEUTICA N.V. (BE) 1979-07-10 — — US claimed
US-4079062-A ANTIMICROBIAL, PLANT GROWTH REGULATORS; 1-(B-ARYL)ETHYL-1H-1,2,4-TRIAZOLE KETALS JANSSEN PHARMACEUTICA N.V. (BE) 1978-03-14 — — US claimed
US-11873291-B2 Quinoline cGAS antagonist compounds IMMUNESENSOR THERAPEUTICS, INC. (US) 2024-01-16 — — US disclosed
US-20220340577-A1 GCN2 INHIBITORS AND USES THEREOF VERTEX PHARMACEUTICALS INCORPORATED 2022-10-27 — — US disclosed
US-10889556-B2 Compositions and methods for inhibiting influenza RNA polymerase PA endonuclease THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-01-12 — — US disclosed
US-20190106398-A1 COMPOSITIONS AND METHODS FOR INHIBITING INFLUENZA RNA POLYMERASE PA ENDONUCLEASE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2019-04-11 — — US disclosed
WO-2011035064-A2 TRIAZOLE CATALYSTS AND METHODS OF MAKING AND USING THE SAME UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2011-03-24 — — WO disclosed
US-20080280836-A1 Anti-hypercholesterolemic biaryl azetidinone compounds MORRIELLO GREGORI J 2008-11-13 — — US disclosed
EP-0576201-B1 Fungicidal 1,2,4-triazoles ROHM & HAAS (US) 2001-08-16 — — EP disclosed
EP-0576199-B1 Fungicidal and herbicidal triazoles ROHM & HAAS (US) 2001-08-01 — — EP disclosed
US-5624916-A Fungicidal 1,2,4-triazoles ROHM AND HAAS COMPANY (US) 1997-04-29 — — US disclosed
US-4598085-A Fungicidal 1-(2-aryl-2-R-ethyl)-1H-1,2,4-triazoles JANSSEN PHARMACEUTICA N.V. (BE) 1986-07-01 — — US disclosed
US-4598085-A Fungicidal 1-(2-aryl-2-R-ethyl)-1H-1,2,4-triazoles JANSSEN PHARMACEUTICA N.V. (BE) 1986-07-01 — — US disclosed
US-4556717-A CATALYTIC HYDROGENATION OF 2-(2,4-DICHLOROPHENYL)-VALERONITRILE CIBA GEIGY CORPORATION (US) 1985-12-03 — — US disclosed
US-4479021-A ESTERIFICATION, PEROXIDATION OF 1-ALKENE WITH FORMIC ACID, AND HYDROGEN PEROXIDE, THEN SAPONIFICATION CIBA-GEIGY CORPORATION (US) 1984-10-23 — — US disclosed
EP-0097617-A1 Method for the production of 1-(2-(,4-dichlorphenyl)pentyl)-1H-1,2,4-triazole and hydrazone- or hydrazine-derivatives CIBA-GEIGY AG (CH) 1984-01-04 — — EP disclosed
US-4391813-A 1-//2-/2,4-DICHLOROPHENYL/-4-ETHYL-1,3-DIOXOLAN-2-YL/METHYL/-1H-1,2,4-TRIAZOLE CORNELL RESEARCH FOUNDATION, INC. (US) 1983-07-05 — — US disclosed
US-4220764-A Preparation of tertiary heterocyclic amines UOP INC. (US) 1980-09-02 — — US disclosed
US-4160838-A FUNGICIDES, BACTERICIDES JANSSEN PHARMACEUTICA N.V. (BE) 1979-07-10 — — US disclosed
US-4079062-A ANTIMICROBIAL, PLANT GROWTH REGULATORS; 1-(B-ARYL)ETHYL-1H-1,2,4-TRIAZOLE KETALS JANSSEN PHARMACEUTICA N.V. (BE) 1978-03-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190106398-A1 COMPOSITIONS AND METHODS FOR INHIBITING INFLUENZA RNA POLYMERASE PA ENDONUCLEASE POLRMT, RNASE1, POLM TBXAS1 1953/4885EGLN3 1862/4885MEN1 3312/4885
US-20080280836-A1 Anti-hypercholesterolemic biaryl azetidinone compounds APOB, PCSK9, CYP46A1 TBXAS1 2138/4885EGLN3 511/4885MEN1 1976/4885
US-11873291-B2 Quinoline cGAS antagonist compounds CGAS, GLS2, GLS TBXAS1 244/4885EGLN3 1404/4885MEN1 1514/4885
US-20220340577-A1 GCN2 INHIBITORS AND USES THEREOF EIF2AK4, GCN1, GCGR TBXAS1 3413/4885EGLN3 1078/4885MEN1 3168/4885
US-10889556-B2 Compositions and methods for inhibiting influenza RNA polymerase PA endonuclease POLRMT, RNASE1, POLM TBXAS1 1953/4885EGLN3 1862/4885MEN1 3312/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.