Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | G6PD | P11413 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | USP8 | P40818 | 2/20 | 0.45 |
| ▸ | USP7 | Q93009 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817043 | 0.84 | ALDH1A1 (0.45) | USP8USP7ALDH1A1KMT2AMEN1 | |
| SCHEMBL7810488 | 0.75 | MAPT (0.51) | MAPTKDM4EMAPK1HTTRAB9A | |
| SCHEMBL7810480 | 0.75 | MAPT (0.51) | MAPTKDM4EMAPK1HTTRAB9A | |
| SCHEMBL7809872 | 0.74 | MEN1 (0.39) | MAPTKDM4EMAPK1RAB9ANPSR1 | |
| SCHEMBL7823380 | 0.74 | ALDH1A1 (0.37) | ALDH1A1KMT2AMEN1TDP1THRB | |
| SCHEMBL11134106 | 0.71 | MAPT (0.73) | MAPTKDM4EMAPK1HTTRAB9A | |
| SCHEMBL8996375 | 0.69 | TOP1 (0.52) | MAPTKDM4EMAPK1HTTRAB9A | |
| SCHEMBL6407586 | 0.68 | MAPT (0.40) | MAPTKDM4EMAPK1HTTRAB9A | |
| SCHEMBL7809098 | 0.67 | TDP2 (0.59) | KMT2AMEN1TDP1THRBHKDC1 | |
| SCHEMBL6407178 | 0.66 | MAPT (0.50) | MAPTKDM4EMAPK1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0750619-B1 | HETERO-ANNULATED INDAZOLES | NOVUSPHARMA SPA (IT) | 2001-05-30 | — | — | EP | disclosed |
| US-5596097-A | ANTITUMOR AGENTS | THE UNIVERSITY OF VERMONT (US) | 1997-01-21 | — | — | US | disclosed |
| EP-0750619-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA S.p.A. (IT) | 1997-01-02 | — | — | EP | disclosed |
| WO-1995024407-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-09-14 | — | — | WO | disclosed |