Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.38 |
| ▸ | CSNK2A3 | Q8NEV1 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817043 | 0.88 | ALDH1A1 (0.45) | MEN1KMT2AALDH1A1TDP1THRB | |
| SCHEMBL3896954 | 0.82 | CSNK2A2 (0.54) | MEN1KMT2AMAPTMAOACSNK2A2 | |
| SCHEMBL7823380 | 0.78 | ALDH1A1 (0.37) | MEN1KMT2ATP53ALDH1A1TDP1 | |
| SCHEMBL7823976 | 0.74 | MAPT (0.48) | MEN1KMT2AMAPTMAOACSNK2A2 | |
| SCHEMBL7811405 | 0.74 | MAPT (0.46) | MEN1KMT2AMAPTMAOAHPGD | |
| SCHEMBL11863082 | 0.73 | MAPT (0.76) | MEN1KMT2AMAPTMAOACSNK2A2 | |
| SCHEMBL7813936 | 0.73 | MAOA (0.49) | MEN1KMT2AMAPTMAOACSNK2A2 | |
| SCHEMBL7819427 | 0.73 | MAOA (0.49) | MEN1KMT2AMAPTMAOACSNK2A2 | |
| SCHEMBL6674009 | 0.72 | CSNK2A2 (0.44) | MEN1KMT2AMAPTMAOACSNK2A2 | |
| SCHEMBL8545907 | 0.70 | TDP2 (0.59) | MEN1KMT2AMAPTMAOAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0750619-B1 | HETERO-ANNULATED INDAZOLES | NOVUSPHARMA SPA (IT) | 2001-05-30 | — | — | EP | disclosed |
| US-5596097-A | ANTITUMOR AGENTS | THE UNIVERSITY OF VERMONT (US) | 1997-01-21 | — | — | US | disclosed |
| EP-0750619-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA S.p.A. (IT) | 1997-01-02 | — | — | EP | disclosed |
| WO-1995024407-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-09-14 | — | — | WO | disclosed |