SCHEMBL7813604

SCHEMBL7813604

CC(C)(Oc1ccc(C2CCN(C(=O)c3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)CC2)cc1)C(=O)O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 3/20 0.46
HSP90AB1 P08238 3/20 0.46
HSD11B1 P28845 1/20 0.45
LMNA P02545 3/20 0.43
PPARA Q07869 2/20 0.43
CYP2C9 P11712 1/20 0.43
TSHR P16473 1/20 0.43
BLM P54132 1/20 0.43
PARP10 Q53GL7 3/20 0.42
BCL9 O00512 1/20 0.42
CTNNB1 P35222 1/20 0.42
PARP14 Q460N5 2/20 0.41
EGLN1 Q9GZT9 1/20 0.40
KCNH2 Q12809 1/20 0.40
TRPC6 Q9Y210 1/20 0.40
MAPK1 P28482 1/20 0.40
MAPK14 Q16539 1/20 0.40
ITGB3 P05106 1/20 0.39
ITGA2B P08514 1/20 0.39
EPHX2 P34913 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7811776 0.89 BCL9 (0.54) HSP90AA1HSP90AB1HSD11B1PPARAPARP10
SCHEMBL7817531 0.88 HSD11B1 (0.46) HSD11B1LMNAPPARACYP2C9TSHR
SCHEMBL7810069 0.84 HSD11B1 (0.59) HSD11B1LMNAPPARACYP2C9TSHR
SCHEMBL7817518 0.83 ITGB3 (0.57) HSP90AA1HSP90AB1LMNAPPARATSHR
SCHEMBL7814130 0.82 LMNA (0.54) HSD11B1LMNAPPARACYP2C9TSHR
SCHEMBL7810206 0.82 HSD11B1 (0.54) HSD11B1LMNAPPARACYP2C9TSHR
SCHEMBL7804429 0.82 HSD11B1 (0.66) HSD11B1LMNAPARP10EGLN1FASN
SCHEMBL7811341 0.81 PARP10 (0.64) HSD11B1LMNAPPARACYP2C9TSHR
SCHEMBL7813621 0.81 HSD11B1 (0.53) HSD11B1LMNAPPARACYP2C9TSHR
SCHEMBL7814102 0.81 HSD11B1 (0.53) HSD11B1LMNAPPARACYP2C9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0607536-B1 Arylamide derivatives SS PHARMACEUTICAL CO (JP) 2001-01-24 EP disclosed
US-5532371-A SIDE EFFECT REDUCTION SS PHARMACEUTICAL CO., LTD. (JP) 1996-07-02 US disclosed
US-5411972-A Arylamide derivatives for treating hyperlipemia SS PHARMACEUTICAL CO., LTD. (JP) 1995-05-02 US disclosed
EP-0607536-A1 Arylamide derivatives SS PHARMACEUTICAL CO., LTD. (JP) 1994-07-27 EP disclosed