SCHEMBL7813625

SCHEMBL7813625

O=C(O)COc1cccc(N2CCN(C(=O)c3cccs3)CC2)c1

nearest known ligand 0.65

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.64
MAPT P10636 4/20 0.63
LMNA P02545 3/20 0.63
ALDH1A1 P00352 9/20 0.63
KCNA5 P22460 2/20 0.56
GAA P10253 3/20 0.55
ALOX12 P18054 1/20 0.55
KMT2A Q03164 2/20 0.55
ITGB3 P05106 2/20 0.55
ITGA2B P08514 2/20 0.55
MEN1 O00255 1/20 0.55
KDM4E B2RXH2 2/20 0.53
THRB P10828 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7813988 0.82 L3MBTL1 (0.58) L3MBTL1MAPTLMNAALDH1A1KCNA5
SCHEMBL9011266 0.81 ALDH1A1 (0.57) L3MBTL1MAPTLMNAALDH1A1KCNA5
SCHEMBL7811910 0.81 L3MBTL1 (0.57) L3MBTL1MAPTLMNAALDH1A1KCNA5
SCHEMBL7814104 0.80 KCNA5 (0.58) L3MBTL1MAPTLMNAALDH1A1KCNA5
SCHEMBL27303876 0.79 MAPT (0.64) L3MBTL1MAPTLMNAALDH1A1KCNA5
SCHEMBL7811474 0.77 MAPT (0.65) L3MBTL1MAPTLMNAALDH1A1GAA
SCHEMBL7814235 0.77 LMNA (0.71) MAPTLMNAALDH1A1GAAKMT2A
SCHEMBL7817566 0.77 MAPT (0.55) L3MBTL1MAPTLMNAALDH1A1KCNA5
SCHEMBL7817516 0.77 L3MBTL1 (0.69) L3MBTL1MAPTLMNAALDH1A1KCNA5
SCHEMBL7813835 0.76 ALDH1A1 (0.57) MAPTLMNAALDH1A1KMT2AITGB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0607536-B1 Arylamide derivatives SS PHARMACEUTICAL CO (JP) 2001-01-24 EP disclosed
US-5532371-A SIDE EFFECT REDUCTION SS PHARMACEUTICAL CO., LTD. (JP) 1996-07-02 US disclosed
US-5411972-A Arylamide derivatives for treating hyperlipemia SS PHARMACEUTICAL CO., LTD. (JP) 1995-05-02 US disclosed
EP-0607536-A1 Arylamide derivatives SS PHARMACEUTICAL CO., LTD. (JP) 1994-07-27 EP disclosed