Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | RORA | P35398 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | RORB | Q92753 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7811025 | 0.86 | SCN10A (0.35) | HTR1DALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL3651143 | 0.84 | PKM (0.50) | HTR1DALDH1A1HSD17B10PKMCYP1A2 | |
| SCHEMBL5982296 | 0.76 | FGFR1 (0.39) | ALDH1A1HSD17B10TDP1CYP1A2MEN1 | |
| SCHEMBL7818433 | 0.74 | FGFR1 (0.38) | ALDH1A1HPGDMEN1GAAKMT2A | |
| SCHEMBL7810834 | 0.70 | KIF11 (0.42) | ALDH1A1PKMCYP1A2CYP2C19 | |
| SCHEMBL21038105 | 0.69 | ALDH1A1 (0.39) | HTR1DALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL762008 | 0.69 | GRM5 (0.49) | HTR1DALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL10254346 | 0.69 | HCAR3 (0.51) | ALDH1A1HPGDHSD17B10PKMMEN1 | |
| SCHEMBL5982464 | 0.69 | HCAR3 (0.55) | HPGDHSD17B10TDP1GAAL3MBTL1 | |
| SCHEMBL75687 | 0.69 | SLC9A1 (0.43) | ALDH1A1HPGDTDP1PKMCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745600-B1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-5886014-A | TREATMENT AND/OR PROPHYLAXIS OF A VARIETY OF DISORDERS, INCLUDING HYPERLIPEMIA, HYPERGLYCEMIA, OBESITY, IMPAIRED GLUCOSE TOLERANCE (IGT), INSULIN RESISTANCE AND DIABETIC COMPLICATIONS | SANKYO COMPANY, LIMITED (JP) | 1999-03-23 | — | — | US | disclosed |
| EP-0745600-A1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1996-12-04 | — | — | EP | disclosed |