Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL27950802 | 0.97 | MEN1 (0.35) | MEN1KMT2AALDH1A1TSHRTDP1 | |
| Silver SCHEMBL153661 | 0.97 | MEN1 (0.35) | MEN1KMT2AALDH1A1TSHRTDP1 | |
| SCHEMBL8038652 | 0.93 | MEN1 (0.38) | MEN1KMT2AALDH1A1TSHRTDP1 | |
| Ammonia Solution, Strong SCHEMBL28956104 | 0.90 | MEN1 (0.44) | MEN1KMT2AALDH1A1TSHRTDP1 | |
| Silver SCHEMBL10906729 | 0.90 | MEN1 (0.35) | MEN1KMT2AALDH1A1TSHRTDP1 | |
| Ammonia Solution, Strong SCHEMBL7104489 | 0.90 | MEN1 (0.44) | MEN1KMT2AALDH1A1TSHRTDP1 | |
| Nitric Acid SCHEMBL7908970 | 0.88 | CA5A (0.47) | MEN1KMT2AALDH1A1TSHR | |
| Potassium Ion SCHEMBL8748 | 0.86 | MEN1 (0.33) | MEN1KMT2AALDH1A1TSHR | |
| Potassium Ion SCHEMBL29775431 | 0.86 | MEN1 (0.33) | MEN1KMT2AALDH1A1TSHR | |
| Nitric Acid SCHEMBL22529491 | 0.85 | CA5A (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144415-A2 | FUNCTIONALIZED HETEROCYCLES AS CHEMOKINE RECEPTOR MODULATORS | WARNER-LAMBERT COMPANY (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000042045-A2 | FUNCTIONALIZED HETEROCYCLES AS CHEMOKINE RECEPTOR MODULATORS | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | disclosed |