Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 15/20 | 0.48 |
| ▸ | GPR17 | Q13304 | 2/20 | 0.42 |
| ▸ | BCL2 | P10415 | 4/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethyne SCHEMBL7605585 | 0.70 | GPR17 (0.45) | GPR17GRIN1 | |
| SCHEMBL7817672 | 0.69 | MEN1 (0.50) | — | |
| SCHEMBL7592453 | 0.68 | GPR35 (0.43) | GPR17 | |
| SCHEMBL7463695 | 0.67 | SLC6A2 (0.41) | MCL1GPR17GRIN1 | |
| SCHEMBL7072708 | 0.67 | GPR17 (0.61) | MCL1GPR17BCL2 | |
| SCHEMBL7076761 | 0.66 | MCL1 (0.48) | MCL1GPR17BCL2 | |
| SCHEMBL5214867 | 0.66 | ALOX5 (0.47) | — | |
| SCHEMBL7842628 | 0.65 | KDM4E (0.47) | MCL1BCL2 | |
| SCHEMBL27873446 | 0.65 | PTPRG (0.56) | — | |
| SCHEMBL7074273 | 0.65 | MDM2 (0.40) | MCL1GPR17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150954-A1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | AstraZeneca AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046198-A1 | ANTI-INFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |