Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.51 |
| ▸ | ESRRA | P11474 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.49 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746166 | 0.92 | MAPT (0.62) | MAOAPOLBMAPTALDH1A1HPGD | |
| SCHEMBL6138266 | 0.90 | MAPT (0.60) | MAOAPOLBMAPTALDH1A1HPGD | |
| SCHEMBL3952992 | 0.83 | KMT2A (0.60) | MAOAPOLBMAPTALDH1A1HPGD | |
| SCHEMBL1176635 | 0.81 | MEN1 (0.69) | MAOAPOLBMAPTALDH1A1KMT2A | |
| SCHEMBL8549110 | 0.80 | RAB9A (0.62) | MAOAPOLBMAPTALDH1A1KMT2A | |
| Anthracene SCHEMBL29076817 | 0.80 | MEN1 (0.67) | MAOAPOLBMAPTALDH1A1KMT2A | |
| SCHEMBL11620429 | 0.79 | ALDH1A1 (0.83) | MAPK14MAPTALDH1A1HPGDAKR1B1 | |
| SCHEMBL7830341 | 0.78 | PDK1 (0.56) | KMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL3776520 | 0.78 | KMT2A (0.65) | MAOAPOLBMAPTALDH1A1KMT2A | |
| SCHEMBL11900180 | 0.78 | CASP6 (0.68) | POLBMAPTALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798288-B1 | TRICICLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2001-05-16 | — | — | EP | disclosed |
| EP-0798288-A1 | TRICICLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-10-01 | — | — | EP | disclosed |