Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.36 |
| ▸ | EDNRB | P24530 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7820028 | 0.88 | CRHR1 (0.34) | CRHR1EDNRBEDNRAMAPK1ALDH1A1 | |
| SCHEMBL7827120 | 0.85 | TLR7 (0.35) | CRHR1 | |
| SCHEMBL7820032 | 0.80 | CRHR1 (0.35) | CRHR1EDNRBEDNRAMAPK1ALDH1A1 | |
| SCHEMBL6894855 | 0.70 | — | — | |
| SCHEMBL7944720 | 0.70 | CRHR1 (0.34) | CRHR1 | |
| SCHEMBL5844675 | 0.68 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL5844265 | 0.66 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL6432632 | 0.65 | ALDH1A1 (0.38) | CRHR1MAPK1ALDH1A1MAPTLMNA | |
| SCHEMBL7477014 | 0.65 | KEAP1 (0.38) | CRHR1ALDH1A1MAPTLMNA | |
| SCHEMBL5844211 | 0.65 | CRHR1 (0.38) | CRHR1MAPK1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901476-A4 | ARYLOXY- AND ARYLTHIO-FUSED PYRIDINES AND PYRIMIDINES AND DERIVATIVES | DU PONT PHARM CO (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6258809-B1 | NERVOUS SYSTEM DISORDERS, ANTIDEPRESSANTS AND PSYCHIATRY | DUPONT PHARMACEUTICALS COMPANY | 2001-07-10 | — | — | US | disclosed |
| US-6124300-A | Aryloxy- and arylthio- fused pyridines and pyrimidines and derivatives | DUPONT PHARMACEUTICALS (US) | 2000-09-26 | — | — | US | disclosed |
| EP-0901476-A1 | ARYLOXY- AND ARYLTHIO-FUSED PYRIDINES AND PYRIMIDINES AND DERIVATIVES | Du Pont Pharmaceuticals Company (US) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997035846-A1 | ARYLOXY- AND ARYLTHIO-FUSED PYRIDINES AND PYRIMIDINES AND DERIVATIVES | DUPONT PHARMACEUTICALS COMPANY (US) | 1997-10-02 | — | — | WO | disclosed |