Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 7/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781144 | 0.83 | CYP3A4 (0.46) | TRPM8HPGDTSHRHTTSIGMAR1 | |
| SCHEMBL11663203 | 0.81 | ALDH1A1 (0.55) | TRPM8HPGDTSHRHTTSIGMAR1 | |
| SCHEMBL26525031 | 0.79 | TRPM8 (0.43) | TRPM8HPGDTSHRHTTSIGMAR1 | |
| SCHEMBL31443047 | 0.79 | TRPM8 (0.46) | TRPM8HPGDTSHRHTTSIGMAR1 | |
| SCHEMBL7815992 | 0.79 | SIGMAR1 (0.47) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA | |
| SCHEMBL7828940 | 0.78 | TP53 (0.49) | TRPM8TSHRALDH1A1LMNACYP3A4 | |
| SCHEMBL12550525 | 0.78 | ALDH1A1 (0.53) | TRPM8TSHRSIGMAR1ALDH1A1HSD17B1 | |
| SCHEMBL7824932 | 0.77 | TSPO (0.44) | ALDH1A1LMNA | |
| SCHEMBL13041465 | 0.77 | ALDH1A1 (0.43) | TRPM8HPGDTSHRHTTSIGMAR1 | |
| SCHEMBL12679911 | 0.77 | HPGD (0.44) | TRPM8HPGDTSHRHTTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686636-B1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA CO (JP) | 2001-04-04 | — | — | EP | disclosed |
| US-5840895-A | INTERMEDIATES FOR ANTIALLERGENS | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1998-11-24 | — | — | US | disclosed |
| US-5686442-A | ANTIALLERGENS | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1997-11-11 | — | — | US | disclosed |
| EP-0686636-A1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1995-12-13 | — | — | EP | disclosed |