Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 13/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 11/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12550525 | 0.83 | ALDH1A1 (0.53) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA | |
| SCHEMBL5042970 | 0.81 | TSPO (0.53) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA | |
| SCHEMBL2090213 | 0.81 | HSD17B1 (0.49) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA | |
| SCHEMBL29674730 | 0.81 | TSPO (0.53) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA | |
| Benzene SCHEMBL28335658 | 0.81 | TRPM8 (0.50) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA | |
| SCHEMBL1029152 | 0.81 | TRPM8 (0.50) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA | |
| SCHEMBL10943951 | 0.79 | SIGMAR1 (0.47) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA | |
| SCHEMBL1029447 | 0.79 | SIGMAR1 (0.47) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA | |
| SCHEMBL5932324 | 0.79 | SIGMAR1 (0.47) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA | |
| SCHEMBL7826537 | 0.79 | TRPM8 (0.45) | SIGMAR1ALDH1A1HSD17B1HSD17B2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686636-B1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA CO (JP) | 2001-04-04 | — | — | EP | disclosed |
| US-5686442-A | ANTIALLERGENS | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1997-11-11 | — | — | US | disclosed |
| EP-0686636-A1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1995-12-13 | — | — | EP | disclosed |