Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.36 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816537 | 0.88 | GPR35 (0.41) | GPR35ALDH1A1HPGDSMN1; SMN2PDK1 | |
| SCHEMBL8345841 | 0.85 | GPR35 (0.39) | GPR35ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL7824213 | 0.82 | RAB9A (0.41) | ALDH1A1MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL7827083 | 0.80 | TYK2 (0.47) | ALDH1A1HPGDSMN1; SMN2KDM4EHTT | |
| SCHEMBL7817437 | 0.80 | ALDH1A1 (0.39) | GPR35ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL8799546 | 0.80 | ALDH1A1 (0.39) | GPR35ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL8341754 | 0.79 | TP53 (0.48) | GPR35ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8799382 | 0.79 | TYK2 (0.37) | GPR35ALDH1A1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL7823819 | 0.78 | GPR35 (0.53) | GPR35ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL7816319 | 0.77 | SMN1; SMN2 (0.47) | ALDH1A1HPGDMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757682-B1 | BENZOFURAN DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION | FUJISAWA PHARMACEUTICAL CO (JP) | 2001-06-20 | — | — | EP | disclosed |
| US-5858995-A | ADMINISTERING TO HUMANS AND ANIMALS IN THE TREATMENT OF DISEASES CAUSED BY ABNORMAL BONE METABOLISM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-01-12 | — | — | US | disclosed |
| EP-0757682-A1 | BENZOFURAN DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029907-A1 | BENZOFURAN DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-09 | — | — | WO | disclosed |