Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 2/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyric Acid SCHEMBL7824759 | 0.89 | HDAC3 (0.46) | APEX1NR4A2KEAP1ALDH1A1CYP2C19 | |
| Chloroacetic Acid SCHEMBL7828347 | 0.86 | ALDH1A1 (0.42) | APEX1ALDH1A1SMN1; SMN2RAB9AHIF1A | |
| Oxalic Acid SCHEMBL30766245 | 0.85 | THRB (0.40) | APEX1ALDH1A1MAPK1TSHRKMT2A | |
| Oxalic Acid SCHEMBL27135274 | 0.85 | THRB (0.40) | APEX1ALDH1A1MAPK1TSHRKMT2A | |
| Oxalic Acid SCHEMBL27003085 | 0.85 | THRB (0.40) | APEX1ALDH1A1MAPK1TSHRKMT2A | |
| SCHEMBL7816656 | 0.84 | SMN1; SMN2 (0.48) | ALDH1A1CYP2C19GAASMN1; SMN2CYP1A2 | |
| Dodecanoate SCHEMBL7824704 | 0.83 | GPR84 (0.53) | ALDH1A1FFAR1HDAC11TSHRKMT2A | |
| Acetic Acid SCHEMBL27003086 | 0.83 | THRB (0.39) | ALDH1A1GAASMN1; SMN2LMNARAB9A | |
| Acetic Acid SCHEMBL7830102 | 0.83 | THRB (0.39) | ALDH1A1GAASMN1; SMN2LMNARAB9A | |
| Methoxyacetic Acid SCHEMBL7827617 | 0.80 | POLB (0.42) | APEX1ALDH1A1CYP2C19SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679640-B1 | Carboxylate and heat-sensitive recording material using same | MITSUI CHEMICALS INC (JP) | 2001-08-08 | — | — | EP | disclosed |
| CN-1114431-A | Carboxylate and heat-sensitive recording material using same | MITSUI TOATSU CHEMICALS (JP) | 1996-01-03 | — | — | CN | disclosed |