Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 3/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16473172 | 0.83 | LMNA (0.38) | HPGDSMN1; SMN2POLBHSD17B10NPC1 | |
| SCHEMBL26842914 | 0.79 | SMN1; SMN2 (0.43) | KDM4EHPGDSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL14307558 | 0.79 | MAPK14 (0.40) | KDM4ENPC1RAB9AKMT2AMEN1 | |
| SCHEMBL16478914 | 0.79 | ALDH1A1 (0.39) | KDM4EHPGDSMN1; SMN2L3MBTL1POLB | |
| SCHEMBL13102550 | 0.79 | CYP11B1 (0.49) | CHEK1KDM4EHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL23329192 | 0.76 | NISCH (0.39) | KDM4EALDH1A1NPC1RAB9AMAPK1 | |
| SCHEMBL23328982 | 0.76 | RAB9A (0.47) | KDM4EHPGDSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL453506 | 0.76 | KDM4E (0.48) | KDM4EHPGDSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL17424258 | 0.75 | LTA4H (0.42) | CHEK1KDM4EHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL28116018 | 0.75 | TDP1 (0.50) | KDM4EHPGDSMN1; SMN2L3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885212-B1 | QUINOXALINEDIONES | PFIZER RES AND BR DEV COMPANY (IE) | 2001-11-14 | — | — | EP | claimed |
| US-4115288-A | Lubricants containing substituted triazoles as antiwear agents | MOBIL OIL CORPORATION (US) | 1978-09-19 | — | — | US | claimed |
| EP-3373920-A1 | METHODS AND COMPOSITIONS FOR TREATING ALCOHOL USE DISORDERS | Sanna, Pietro Paolo (US) | 2018-09-19 | — | — | EP | disclosed |
| US-10039772-B2 | Methods and compositions for treating alcohol use disorders | SANNA PIETRO PAOLO (US) | 2018-08-07 | — | — | US | disclosed |
| CN-107417634-A | A kind of method that two alkane of selectivity synthesis nitrogen are acylated 1,2,3 triazole compounds | 武汉工程大学 | 2017-12-01 | — | — | CN | disclosed |
| CN-107286106-A | A kind of two alkane of selectivity synthesis nitrogen are acylated the new method of 1,2,3 triazole compounds | 武汉工程大学 | 2017-10-24 | — | — | CN | disclosed |
| US-20170232007-A1 | METHODS AND COMPOSITIONS FOR TREATING ALCOHOL USE DISORDERS | SANNA PIETRO PAOLO (US) | 2017-08-17 | — | — | US | disclosed |
| WO-2017083795-A1 | METHODS AND COMPOSITIONS FOR TREATING ALCOHOL USE DISORDERS | SANNA PIETRO PAOLO (US) | 2017-05-18 | — | — | WO | disclosed |
| CN-106146418-A | A kind of synthetic method of NH-1,2,3-triazole compounds | 海南师范大学 | 2016-11-23 | — | — | CN | disclosed |
| US-7709655-B2 | Clickphosphines for transition metal-catalyzed reactions | THE PENN STATE RESEARCH FOUNDATION (US) | 2010-05-04 | — | — | US | disclosed |
| US-20090239982-A1 | Ultraviolet Absorbent and Heterocyclic Compound | FUJIFILM CORPORATION (JP) | 2009-09-24 | — | — | US | disclosed |
| US-20090239982-A1 | Ultraviolet Absorbent and Heterocyclic Compound | FUJIFILM CORPORATION (JP) | 2009-09-24 | — | — | US | disclosed |
| US-20070088166-A1 | Clickphosphines for transition metal-catalyzed reactions | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-04-19 | — | — | US | disclosed |
| WO-1998018791-A1 | HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1998-05-07 | — | — | WO | disclosed |
| US-4115288-A | Lubricants containing substituted triazoles as antiwear agents | MOBIL OIL CORPORATION (US) | 1978-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10039772-B2 | Methods and compositions for treating alcohol use disorders | HSD3B1, HSD11B1, HSD3B2 | AKT2 738/4885CHEK1 4771/4885KDM4E 3167/4885 |
| US-20090239982-A1 | Ultraviolet Absorbent and Heterocyclic Compound | CYP2A6, CYP2B6, XPO6 | AKT2 4336/4885CHEK1 1804/4885KDM4E 2273/4885 |
| US-20170232007-A1 | METHODS AND COMPOSITIONS FOR TREATING ALCOHOL USE DISORDERS | HSD3B1, HSD11B1, HSD3B2 | AKT2 738/4885CHEK1 4771/4885KDM4E 3167/4885 |
| US-20070088166-A1 | Clickphosphines for transition metal-catalyzed reactions | WEE1, WEE2, ITK | AKT2 753/4885CHEK1 102/4885KDM4E 1779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.