SCHEMBL7833003

SCHEMBL7833003

CC(=O)Nc1cccc2c1C(=O)c1ccccc1CO2

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.59
RAB9A P51151 2/20 0.50
NPC1 O15118 1/20 0.50
CASP3 P42574 1/20 0.49
ALDH1A1 P00352 4/20 0.48
KDM4E B2RXH2 1/20 0.48
GAA P10253 1/20 0.48
HPGD P15428 1/20 0.48
HSD17B10 Q99714 1/20 0.48
MAPT P10636 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
MAOB P27338 1/20 0.46
MAPK14 Q16539 5/20 0.43
CCNE2 O96020 4/20 0.43
CCNE1 P24864 4/20 0.43
CDK2 P24941 4/20 0.43
CDK4 P11802 1/20 0.43
CCND1 P24385 1/20 0.43
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7831455 0.81 PDK1 (0.49)
SCHEMBL9279689 0.81 MAOA (0.66) MAOARAB9ANPC1CASP3ALDH1A1
SCHEMBL7820597 0.80 CCNE2 (0.43) MAOARAB9ANPC1CASP3ALDH1A1
SCHEMBL20334273 0.76 MAOA (0.90) MAOARAB9ACASP3ALDH1A1KDM4E
SCHEMBL343377 0.76 ALDH1A1 (0.60) MAOARAB9ANPC1CASP3ALDH1A1
SCHEMBL4219979 0.76 MAPK14 (0.68) MAPK14
SCHEMBL2601918 0.75 MAOA (1.00) MAOARAB9ANPC1CASP3ALDH1A1
SCHEMBL7818784 0.75 MAOA (0.87) MAOARAB9ACASP3ALDH1A1KDM4E
Acetic Acid SCHEMBL343375 0.74 MAPT (0.63) MAOARAB9ANPC1ALDH1A1KDM4E
SCHEMBL343281 0.74 KEAP1 (0.53) MAOARAB9ANPC1ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0798288-B1 TRICICLIC COMPOUNDS KYOWA HAKKO KOGYO KK (JP) 2001-05-16 EP disclosed
EP-0798288-A1 TRICICLIC COMPOUNDS KYOWA HAKKO KOGYO CO., LTD. (JP) 1997-10-01 EP disclosed