SCHEMBL7833797

SCHEMBL7833797

CCS(=O)(=O)Nc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PSIP1 O75475 1/20 0.33
PGR P06401 3/20 0.33
BRPF1 P55201 1/20 0.31
PPOX P50336 1/20 0.30
BRAF P15056 1/20 0.30
MAPT P10636 1/20 0.30
BRD4 O60885 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8762906 0.93 BRAF (0.36) BRAFMAPT
SCHEMBL9679435 0.91 PPOX (0.35) PGRBRPF1PPOXMAPT
SCHEMBL5361878 0.89 PPOX (0.40) BRPF1PPOXMAPTBRD4
SCHEMBL7821029 0.89 BRAF (0.30) PPOXBRAF
SCHEMBL8463248 0.88 PSIP1 (0.33) PSIP1PPOX
SCHEMBL7987004 0.87 PSIP1 (0.33) PSIP1PGRBRPF1BRD4
SCHEMBL8461514 0.86 PPOX (0.32) BRPF1PPOX
SCHEMBL7951096 0.86 BRD9 (0.31)
SCHEMBL7212890 0.85 PGR (0.39) PSIP1PGRBRD4
SCHEMBL8696878 0.85

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0563384-B1 URACIL DERIVATIVE NISSAN CHEMICAL IND LTD (JP) 2001-10-04 EP disclosed
US-5990044-A Selective herbicides based on aryl uracils BAYER AKTIENGESELLSCHAFT (DE) 1999-11-23 US disclosed
US-5900483-A Process for the separation of phenyluracil compounds NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1999-05-04 US disclosed
EP-0496595-B1 Aniline derivatives and process for producing the same NISSAN CHEMICAL IND LTD (JP) 1995-09-06 EP disclosed
US-5416236-A Sulfonylation, reduction and carbamylation in multistage process NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1995-05-16 US disclosed
US-5356863-A Herbicides NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1994-10-18 US disclosed
EP-0563384-A1 URACIL DERIVATIVE NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1993-10-06 EP disclosed
EP-0496595-A1 Aniline derivatives and process for producing the same NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1992-07-29 EP disclosed