Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | FABP4 | P15090 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.50 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.50 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | YAP1 | P46937 | 1/20 | 0.47 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.47 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29050682 | 0.88 | NPC1 (0.51) | MAPTALOX15FABP4GAAMEN1 | |
| SCHEMBL27727061 | 0.87 | MAPT (0.47) | MAPTALOX15FABP4GAAMEN1 | |
| SCHEMBL12112435 | 0.86 | MAPT (0.58) | MAPTALOX15FABP4MEN1KMT2A | |
| Fenamic Acid SCHEMBL28097929 | 0.84 | FABP4 (0.79) | MAPTALOX15FABP4MEN1KMT2A | |
| SCHEMBL7835113 | 0.82 | YAP1 (0.65) | MAPTALOX15FABP4GAAMEN1 | |
| SCHEMBL12983141 | 0.81 | MEN1 (0.55) | MAPTGAAMEN1KMT2ANPC1 | |
| SCHEMBL14575409 | 0.81 | AKR1C3 (0.47) | MAPTALOX15FABP4GAAMEN1 | |
| SCHEMBL14853341 | 0.80 | YAP1 (0.77) | MAPTGAAALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL7959032 | 0.79 | ALDH1A1 (0.45) | MAPTGAAKMT2ANPC1ALDH1A1 | |
| SCHEMBL605325 | 0.79 | KDM4E (0.58) | MAPTFABP4GAAKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783505-B1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2001-03-07 | — | — | EP | disclosed |
| CN-1046731-C | Pyrrolo [2,3-d ] pyrimidines and their use | NOVARTIS AG (CH) | 1999-11-24 | — | — | CN | disclosed |
| US-5869485-A | Pyrrolo 2,3-d!pyrimidines and their use | NOVARTIS FINANCE CORP. (US) | 1999-02-09 | — | — | US | disclosed |
| CN-1164234-A | Pyrrolo [2, 3-d ] pyrimidines and their use | NOVARTIS AG (CH) | 1997-11-05 | — | — | CN | disclosed |
| EP-0783505-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | Novartis AG (CH) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996010028-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 1996-04-04 | — | — | WO | disclosed |