Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7837784 | 0.90 | LMNA (0.51) | MMP2MMP8PTGS1PTGS2LMNA | |
| SCHEMBL7838561 | 0.90 | FLT1 (0.54) | SMN1; SMN2PTGS1PTGS2EGFRERBB2 | |
| SCHEMBL7836330 | 0.84 | FLT1 (0.50) | SMN1; SMN2MMP2MMP8EGFRERBB2 | |
| SCHEMBL7837954 | 0.81 | MMP1 (0.47) | MMP2MMP8 | |
| SCHEMBL11223447 | 0.76 | EGFR (0.53) | SMN1; SMN2EGFRERBB2MEN1KMT2A | |
| SCHEMBL11221787 | 0.76 | EGFR (0.53) | KDM4ESMN1; SMN2PTGS1PTGS2EGFR | |
| SCHEMBL11543955 | 0.76 | GAA (0.49) | KDM4ESMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL11543953 | 0.76 | GAA (0.49) | KDM4ESMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL11566550 | 0.73 | KDM4E (0.54) | KDM4ESMN1; SMN2LARS1PTGS1PTGS2 | |
| SCHEMBL1499131 | 0.72 | ALDH1A1 (0.48) | SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721944-B1 | IMIDAZOLIDINE DERIVATIVE AND USE THEREOF | SUNTORY LTD (JP) | 2001-01-17 | — | — | EP | disclosed |
| US-5691335-A | CARDIOVASCULAR DISORDERS | SUNTORY LIMITED (JP) | 1997-11-25 | — | — | US | disclosed |
| EP-0721944-A1 | IMIDAZOLIDINE DERIVATIVE AND USE THEREOF | SUNTORY LIMITED (JP) | 1996-07-17 | — | — | EP | disclosed |