Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 8/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GRK2 | P25098 | 2/20 | 0.33 |
| ▸ | GRK3 | P35626 | 2/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7345772 | 0.74 | GPR132 (0.39) | ALDH1A1 | |
| SCHEMBL27486186 | 0.73 | ITGB1 (0.39) | SMN1; SMN2TP53TSHRRAB9ANPSR1 | |
| SCHEMBL7336956 | 0.73 | ITGB3 (0.45) | — | |
| SCHEMBL6778203 | 0.69 | CTSS (0.47) | SMN1; SMN2NPSR1ALDH1A1POLB | |
| SCHEMBL6780118 | 0.69 | ITGB3 (0.47) | HTTL3MBTL1 | |
| SCHEMBL6778846 | 0.68 | KMT2A (0.36) | SMN1; SMN2NPSR1L3MBTL1LMNA | |
| SCHEMBL6779680 | 0.68 | GPR139 (0.45) | — | |
| SCHEMBL7344227 | 0.67 | HTT (0.40) | SMN1; SMN2RAB9ACCR2HTTL3MBTL1 | |
| SCHEMBL27502755 | 0.66 | ITGB3 (0.41) | SMN1; SMN2NPSR1HTTL3MBTL1LMNA | |
| SCHEMBL7339304 | 0.66 | ITGB3 (0.45) | HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | disclosed |
| US-6028223-A | AN INTEGRIN ANTAGONISTS TREATING BONE DISORDER, PERIODONTAL DISEASE, OSTEOPOROSIS, HUMORAL HYPERCALCEMIA OF MALIGNANCY, PAGET'S DISEASE, TUMOR ANGIOGENESIS, DIABETIC RETINOPATHY, ARTHRITIS, SMOOTH MUSCLE CELL MIGRATION AND RESTENOSIS | G. D. SEARLE & CO. (US) | 2000-02-22 | — | — | US | disclosed |