Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.39 |
| ▸ | CTSV | O60911 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 6/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.39 |
| ▸ | ITGAV | P06756 | 5/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 5/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 6/20 | 0.38 |
| ▸ | MDM4 | O15151 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775970 | 0.89 | GPR132 (0.49) | GPR132ITGB1ITGB3ITGAVITGA5 | |
| SCHEMBL7838300 | 0.87 | ITGB3 (0.51) | GPR132CTSVCTSLCTSBCTSS | |
| SCHEMBL6772224 | 0.87 | CTSV (0.50) | GPR132CTSVCTSLCTSBCTSS | |
| SCHEMBL6773776 | 0.86 | CTSB (0.43) | GPR132CTSVCTSLCTSBCTSS | |
| SCHEMBL7340682 | 0.86 | ALDH1A1 (0.47) | GPR132CTSVCTSLCTSBCTSS | |
| SCHEMBL6778268 | 0.85 | GPR139 (0.44) | GPR132CTSVCTSLCTSBCTSS | |
| SCHEMBL3051751 | 0.84 | GPR139 (0.44) | GPR132CTSVCTSLCTSBCTSS | |
| SCHEMBL7823171 | 0.84 | ITGB3 (0.50) | GPR132ITGB1ITGB3ITGAVITGA5 | |
| SCHEMBL7339636 | 0.84 | GPR132 (0.50) | GPR132GPR139ALDH1A1KMT2A | |
| SCHEMBL6778084 | 0.84 | GPR139 (0.45) | GPR132CTSVCTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |
| US-6028223-A | AN INTEGRIN ANTAGONISTS TREATING BONE DISORDER, PERIODONTAL DISEASE, OSTEOPOROSIS, HUMORAL HYPERCALCEMIA OF MALIGNANCY, PAGET'S DISEASE, TUMOR ANGIOGENESIS, DIABETIC RETINOPATHY, ARTHRITIS, SMOOTH MUSCLE CELL MIGRATION AND RESTENOSIS | G. D. SEARLE & CO. (US) | 2000-02-22 | — | — | US | claimed |
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |