Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | NQO1 | P15559 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847660 | 0.86 | HTR2A (0.48) | TSHRHTR2AHTR2CHTR2BGAA | |
| SCHEMBL10461617 | 0.82 | PTGS2 (0.42) | TSHRHTR2AHTR2CHTR2BGAA | |
| SCHEMBL7834430 | 0.79 | HTR1A (0.51) | ALDH1A1GAASMN1; SMN2LMNAMEN1 | |
| SCHEMBL7836633 | 0.78 | TSHR (0.36) | TSHRALDH1A1GAAHSD17B10NQO1 | |
| SCHEMBL1299746 | 0.78 | NCOA1 (0.46) | TSHRALDH1A1SMN1; SMN2HSD17B10LMNA | |
| SCHEMBL6627059 | 0.76 | ALDH1A1 (0.37) | TSHRALDH1A1GAASMN1; SMN2HSD17B10 | |
| SCHEMBL4729044 | 0.75 | NQO1 (0.36) | TSHRHTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL1451009 | 0.75 | CYP1A2 (0.42) | TSHRALDH1A1SMN1; SMN2LMNAGLA | |
| SCHEMBL11117185 | 0.73 | L3MBTL1 (0.36) | ALDH1A1LMNAMEN1KMT2APOLB | |
| SCHEMBL455275 | 0.73 | NQO1 (0.35) | TSHRHTR2AHTR2CHTR2BNQO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 276 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210138117-A1 | COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2021-05-13 | — | — | US | claimed |
| EP-3038621-B1 | COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR | HUMAN BIOMOLECULAR RES INSTITUTE (US) | 2020-12-02 | — | — | EP | claimed |
| EP-3038621-A2 | COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR | Human Biomolecular Research Institute (US) | 2016-07-06 | — | — | EP | claimed |
| US-20160038641-A1 | COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2016-02-11 | — | — | US | claimed |
| WO-2014146039-A2 | COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2014-09-18 | — | — | WO | claimed |
| US-7691843-B2 | N-hydroxyamide derivatives possessing antibacterial activity | PFIZER INC. (US) | 2010-04-06 | — | — | US | claimed |
| US-20080058304-A1 | N-hydroxyamide derivatives possessing antibacterial activity | VICURON HOLDINGS LLC | 2008-03-06 | — | — | US | claimed |
| EP-1576110-A4 | CELL MIGRATION INHIBITING COMPOSITIONS AND METHODS AND COMPOSITIONS FOR TREATING CANCER | AVOLIX PHARMACEUTICALS (US) | 2007-11-07 | — | — | EP | claimed |
| EP-1218337-B1 | SYNTHESIS OF 3,5,7|-1H-IMIDAZO 1,5-A|IMIDAZOL-2(3H)-ONE COMPOUNDS | TORREY PINES INST (US) | 2007-10-31 | — | — | EP | claimed |
| US-20060128742-A1 | Cell migration inhibiting compositions and methods and compositions for treating cancer | AVOLIX PHARMACEUTICALS, INC. | 2006-06-15 | — | — | US | claimed |
| US-6162930-A | Anti-mitotic agents which inhibit tubulin polymerization | BAYLOR UNIVERSITY (US) | 2000-12-19 | — | — | US | claimed |
| EP-0984954-A1 | ANTI-MITOTIC AGENTS WHICH INHIBIT TUBULIN POLYMERIZATION | BAYLOR UNIVERSITY (US) | 2000-03-15 | — | — | EP | claimed |
| US-5886025-A | METHOXY AND ETHOXY SUBSTITUTED 3-AROYL-2-ARYLBENZO(B)THIOPHENES AND BENZO(B)THIOPHENE ANALOGUES | BAYLOR UNIVERSITY (US) | 1999-03-23 | — | — | US | claimed |
| US-5856107-A | Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein | TREGA BIOSCIENCES, INC. (US) | 1999-01-05 | — | — | US | claimed |
| WO-1998039323-A1 | ANTI-MITOTIC AGENTS WHICH INHIBIT TUBULIN POLYMERIZATION | BAYLOR UNIVERSITY (US) | 1998-09-11 | — | — | WO | claimed |
| WO-1998034112-A1 | COMBINATORIAL LIBRARIES OF IMIDAZOL-PYRIDO-INDOLES AND IMIDAZOL-PYRIDO-BENZOTHIOPHENE DERIVATIVES | TREGA BIOSCIENCES, INC. (US) | 1998-08-06 | — | — | WO | claimed |
| US-5753663-A | 5HT2C ANTAGONIST, USEFUL FOR TREATING ANXIETY, PAIN, OBSESSIVE COMPULSIVE DISORDER, ALCOHOLISM, DEPRESSION, MIGRAINE, SLEEP DISORDER, ANOREXIA NERVOSA AND PRIAPISM | SYNTEX (U.S.A.) INC. (US) | 1998-05-19 | — | — | US | claimed |
| WO-1994006797-A1 | NOVEL BIOREDUCTIVE AGENTS | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1994-03-31 | — | — | WO | claimed |
| US-4863963-A | 5-A-REDUCTASE INHIBITOR | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | claimed |
| EP-0294937-A2 | Novel cinnamoylamide derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-12-14 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128742-A1 | Cell migration inhibiting compositions and methods and compositions for treating cancer | MKI67, DCX, NUDC | TSHR 4695/4885HTR2A 4786/4885HTR2C 4811/4885 |
| US-20210138117-A1 | COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR | BMP2, BMP4, BMP6 | TSHR 2887/4885HTR2A 4601/4885HTR2C 4810/4885 |
| US-20160038641-A1 | COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR | BMP2, BMP4, BMP6 | TSHR 3898/4885HTR2A 4684/4885HTR2C 4848/4885 |
| US-20080058304-A1 | N-hydroxyamide derivatives possessing antibacterial activity | AMDHD2, OGA, ENGASE | TSHR 3540/4885HTR2A 1093/4885HTR2C 1737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.