Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.40 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840407 | 0.85 | OPRD1 (0.48) | LMNASMN1; SMN2NPSR1OPRD1OPRK1 | |
| SCHEMBL7840126 | 0.77 | MEN1 (0.50) | LMNASMN1; SMN2HTTALDH1A1MAPT | |
| SCHEMBL30996465 | 0.74 | SLC6A2 (0.47) | LMNASMN1; SMN2ALDH1A1HRH2HRH1 | |
| SCHEMBL30996468 | 0.74 | SLC6A2 (0.47) | LMNASMN1; SMN2ALDH1A1HRH2HRH1 | |
| SCHEMBL7839338 | 0.74 | CACNA1F (0.44) | LMNASMN1; SMN2CNR1HTTNPSR1 | |
| SCHEMBL3028258 | 0.73 | ALDH1A1 (0.49) | LMNASMN1; SMN2ALDH1A1HRH2HRH1 | |
| SCHEMBL2662019 | 0.71 | ALDH1A1 (0.67) | LMNASMN1; SMN2HTTNPSR1ALDH1A1 | |
| SCHEMBL8301729 | 0.71 | MGLL (0.64) | LMNASMN1; SMN2ALDH1A1HRH2HRH1 | |
| SCHEMBL7845340 | 0.71 | OPRD1 (0.46) | LMNASMN1; SMN2OPRD1OPRK1ALDH1A1 | |
| SCHEMBL7002207 | 0.70 | ALDH1A1 (0.53) | LMNASMN1; SMN2NPSR1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |