Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 8/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 8/20 | 0.44 |
| ▸ | CACNA1S | Q13698 | 8/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 8/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7839337 | 0.74 | LMNA (0.46) | CACNA1FCACNA1DCACNA1SCACNA1CSMN1; SMN2 | |
| SCHEMBL7845341 | 0.71 | ELANE (0.37) | SMN1; SMN2LMNAALDH1A1MAPTMEN1 | |
| SCHEMBL3974762 | 0.68 | RAB9A (0.44) | SMN1; SMN2NPSR1LMNAALDH1A1TDP1 | |
| SCHEMBL6190022 | 0.67 | L3MBTL1 (0.60) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3389458 | 0.67 | KMT2A (0.57) | CACNA1FCACNA1DCACNA1SCACNA1CSMN1; SMN2 | |
| SCHEMBL7840126 | 0.67 | MEN1 (0.50) | SMN1; SMN2LMNAHTTALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7832311 | 0.67 | SSTR4 (0.50) | NPSR1LMNAHTTALDH1A1MAPT | |
| SCHEMBL962133 | 0.66 | OPRM1 (0.62) | SMN1; SMN2LMNAHTTALDH1A1MEN1 | |
| SCHEMBL7570691 | 0.65 | SMN1; SMN2 (0.50) | SMN1; SMN2NPSR1LMNAHTTALDH1A1 | |
| SCHEMBL1144551 | 0.65 | MGLL (0.62) | SMN1; SMN2LMNAALDH1A1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |