Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 6/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.46 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HRH2 | P25021 | 4/20 | 0.39 |
| ▸ | HRH1 | P35367 | 4/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8442335 | 0.83 | OPRD1 (0.43) | OPRD1OPRK1LMNAPOLB | |
| SCHEMBL7840407 | 0.81 | OPRD1 (0.48) | OPRD1OPRK1SMN1; SMN2LMNAPOLB | |
| SCHEMBL7838387 | 0.76 | PKM (0.44) | NOS3NOS1NOS2LMNAPOLB | |
| SCHEMBL7845341 | 0.72 | ELANE (0.37) | SMN1; SMN2LMNAALDH1A1KDM4ESMYD3 | |
| SCHEMBL9037444 | 0.71 | OPRD1 (0.51) | OPRD1OPRK1SMN1; SMN2LMNAPOLB | |
| SCHEMBL7839337 | 0.71 | LMNA (0.46) | OPRD1OPRK1SMN1; SMN2LMNAPOLB | |
| SCHEMBL27396277 | 0.69 | OPRD1 (0.51) | OPRD1OPRK1NOS2SMN1; SMN2LMNA | |
| SCHEMBL1447090 | 0.69 | OPRD1 (0.56) | OPRD1OPRK1SMN1; SMN2LMNAPOLB | |
| SCHEMBL30659245 | 0.69 | SMN1; SMN2 (0.56) | OPRD1OPRK1SMN1; SMN2LMNAPOLB | |
| SCHEMBL346648 | 0.69 | SMN1; SMN2 (0.56) | OPRD1OPRK1SMN1; SMN2LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |