Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 3/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | SORD | Q00796 | 2/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 2/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4527918 | 0.81 | ADRB2 (0.46) | DPP4SLC6A7DRD2 | |
| SCHEMBL4558300 | 0.81 | SLC6A9 (0.44) | DPP4HTR2CSLC6A7DRD2DRD4 | |
| SCHEMBL6636788 | 0.78 | HRH4 (0.51) | HRH4HCAR2DPP4DPP7HTR2C | |
| SCHEMBL1774568 | 0.78 | HTR6 (0.58) | DRD2 | |
| SCHEMBL7845835 | 0.77 | SLC6A7 (0.43) | SLC6A7SMODRD2 | |
| SCHEMBL3460721 | 0.76 | LMNA (0.59) | SMO | |
| SCHEMBL6971671 | 0.76 | HTR2A (0.45) | HTR2CSLC6A7 | |
| SCHEMBL29252729 | 0.76 | AGTR2 (0.48) | SLC6A7DRD2 | |
| SCHEMBL1775509 | 0.75 | SLC6A7 (0.35) | SLC6A7 | |
| SCHEMBL29230309 | 0.74 | KIT (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147083-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000040554-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |