Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 12/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852593 | 0.90 | LMNA (0.46) | TP53LMNAMAPTSIRT1KIF11 | |
| SCHEMBL7680170 | 0.88 | LMNA (0.52) | TP53LMNAMAPTSIRT1HPGD | |
| SCHEMBL7853673 | 0.87 | MAPKAPK2 (0.49) | TP53LMNAMAPTSIRT1SMN1; SMN2 | |
| SCHEMBL7843919 | 0.87 | ABCG2 (0.55) | SIRT1KIF11ALDH1A1ABCB1ABCG2 | |
| SCHEMBL7854615 | 0.86 | KIF11 (0.52) | SIRT1KIF11ALDH1A1MAPKAPK2ABCB1 | |
| SCHEMBL7855705 | 0.85 | SIRT1 (0.45) | TP53LMNAMAPTSIRT1KIF11 | |
| SCHEMBL7853658 | 0.84 | SIRT1 (0.46) | TP53LMNAMAPTSIRT1KIF11 | |
| SCHEMBL7847564 | 0.84 | SIRT1 (0.47) | MAPTSIRT1KIF11MAPKAPK2ABCB1 | |
| SCHEMBL7680030 | 0.84 | SIRT1 (0.62) | TP53LMNASIRT1ALOX15KIF11 | |
| SCHEMBL7853788 | 0.83 | SIRT1 (0.46) | SIRT1KIF11MAPKAPK2ABCB1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070716-A1 | Beta-carboline derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-01-24 | — | — | EP | disclosed |