Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 9/20 | 0.45 |
| ▸ | KIF11 | P52732 | 8/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844124 | 0.90 | KIF11 (0.40) | SIRT1KIF11MAPTALDH1A1 | |
| SCHEMBL7683829 | 0.88 | LMNA (0.46) | SIRT1KIF11LMNATP53MAPT | |
| SCHEMBL7843396 | 0.85 | TP53 (0.57) | SIRT1KIF11LMNATP53MAPT | |
| SCHEMBL7855327 | 0.85 | KIF11 (0.47) | SIRT1KIF11MAPTMAPKAPK2SIRT2 | |
| SCHEMBL7847564 | 0.85 | SIRT1 (0.47) | SIRT1KIF11MAPTMAPKAPK2SIRT2 | |
| SCHEMBL7854615 | 0.85 | KIF11 (0.52) | SIRT1KIF11MAPKAPK2SIRT2SIRT3 | |
| SCHEMBL7843919 | 0.84 | ABCG2 (0.55) | SIRT1KIF11ALDH1A1 | |
| SCHEMBL7852593 | 0.84 | LMNA (0.46) | SIRT1KIF11LMNATP53MAPT | |
| SCHEMBL7851002 | 0.83 | DHODH (0.54) | SIRT1KIF11MAPT | |
| SCHEMBL7853413 | 0.83 | MAPT (0.55) | SIRT1KIF11MAPTMAPKAPK2SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070716-A1 | Beta-carboline derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-01-24 | — | — | EP | disclosed |