Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28349448 | 0.82 | PSIP1 (0.42) | PARP1ALDH1A1 | |
| SCHEMBL27895663 | 0.80 | RPS6KB1 (0.46) | MAPK8MAOBPARP10RPS6KB1PARP1 | |
| SCHEMBL184570 | 0.80 | MAPK8 (0.39) | MAPK8MAOBPARP10RPS6KB1ALDH1A1 | |
| SCHEMBL28974830 | 0.76 | MAPT (0.40) | MAPK8MAOBPARP10RPS6KB1ALDH1A1 | |
| SCHEMBL28128227 | 0.75 | LMNA (0.44) | MAPK8MAOBDGAT1ALDH1A1LMNA | |
| SCHEMBL28127954 | 0.75 | DGAT1 (0.51) | MAPK8PARP10RPS6KB1DGAT1PARP1 | |
| SCHEMBL28658004 | 0.75 | RPS6KB1 (0.42) | MAPK8MAOBPARP10RPS6KB1PARP1 | |
| SCHEMBL27970605 | 0.74 | MAPK8 (0.39) | MAPK8MAOBPARP10RPS6KB1ALDH1A1 | |
| SCHEMBL9018997 | 0.72 | KMT2A (0.39) | DGAT1PARP1ALDH1A1LMNA | |
| SCHEMBL1990289 | 0.71 | CYP3A4 (0.50) | PARP10RPS6KB1ALDH1A1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150565-A1 | THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION bioscience AG (DE) | 2001-11-07 | — | — | EP | claimed |
| WO-2000045635-A1 | THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2000-08-10 | — | — | WO | claimed |