Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SLC10A2 | Q12908 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | CDC25C | P30307 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7845064 | 0.87 | ALDH1A1 (0.37) | CYP1A2CYP2C19BAZ1ACYP3A4SLC10A2 | |
| SCHEMBL7837573 | 0.86 | ENPP1 (0.33) | CYP1A2CYP2C19BAZ1ACYP3A4SLC10A2 | |
| SCHEMBL7846693 | 0.86 | LIMK1 (0.33) | LMNAMEN1KMT2AMAPTHTT | |
| SCHEMBL7848483 | 0.83 | LMNA (0.37) | CYP1A2CYP2C19BAZ1ACYP3A4SLC10A2 | |
| SCHEMBL7837233 | 0.81 | MEN1 (0.35) | SLC10A2LMNAMEN1KMT2AMAPT | |
| SCHEMBL7838190 | 0.81 | LMNA (0.41) | CYP1A2CYP2C19CYP3A4SLC10A2LMNA | |
| SCHEMBL7846879 | 0.78 | CA1 (0.38) | CYP1A2CYP2C19BAZ1ACYP3A4LMNA | |
| SCHEMBL7848445 | 0.78 | SLC10A2 (0.35) | CYP1A2CYP2C19BAZ1ACYP3A4SLC10A2 | |
| SCHEMBL7845061 | 0.77 | BAZ1A (0.36) | CYP1A2CYP2C19BAZ1ACYP3A4SLC10A2 | |
| SCHEMBL7848540 | 0.77 | TBXA2R (0.37) | CYP1A2CYP2C19BAZ1ACYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155007-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. Searle LLC (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047568-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. SEARLE LLC (US) | 2000-08-17 | — | — | WO | disclosed |