Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 5/20 | 0.35 |
| ▸ | CTSL | P07711 | 4/20 | 0.35 |
| ▸ | CTSS | P25774 | 3/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7848203 | 0.89 | L3MBTL1 (0.35) | SCN5ASCN9ACTSKCTSLCTSS | |
| SCHEMBL7849143 | 0.88 | HDAC1 (0.41) | HDAC1HDAC6HDAC3HDAC2SCN5A | |
| SCHEMBL7955667 | 0.82 | MMP1 (0.40) | MMP8MMP2MMP9ADAM17MMP1 | |
| SCHEMBL7836622 | 0.82 | SIGMAR1 (0.34) | MMP9MMP1 | |
| SCHEMBL7955182 | 0.80 | MEN1 (0.39) | HDAC1HDAC6HDAC3HDAC2SCN5A | |
| SCHEMBL7848201 | 0.77 | L3MBTL1 (0.36) | SCN5ASCN9ACTSKCTSLCTSS | |
| SCHEMBL7946527 | 0.75 | MMP1 (0.43) | MMP8MMP2MMP9ADAM17MMP1 | |
| SCHEMBL7946524 | 0.75 | MMP1 (0.43) | MMP8MMP2MMP9ADAM17MMP1 | |
| SCHEMBL7955660 | 0.74 | XIAP (0.35) | XIAPBIRC2CTSKCTSLCTSS | |
| SCHEMBL7955777 | 0.74 | MMP1 (0.45) | MMP8MMP2MMP9ADAM17MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137640-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000035885-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |