Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | SSTR2 | P30874 | 3/20 | 0.32 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.32 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836618 | 0.87 | MMP1 (0.36) | SIGMAR1MMP1MMP3MMP9MAPT | |
| SCHEMBL7849232 | 0.82 | HDAC1 (0.40) | MMP1MMP9 | |
| SCHEMBL7848203 | 0.80 | L3MBTL1 (0.35) | MMP3MEN1KMT2APOLB | |
| SCHEMBL7955182 | 0.80 | MEN1 (0.39) | MMP1MMP3MMP9MAPTMEN1 | |
| SCHEMBL7838763 | 0.80 | MMP3 (0.36) | SIGMAR1MMP1MMP3MMP9MAPT | |
| SCHEMBL7838759 | 0.80 | MMP3 (0.36) | SIGMAR1MMP1MMP3MMP9MAPT | |
| SCHEMBL7850472 | 0.77 | MMP3 (0.37) | MMP1MMP3MMP9MAPTMEN1 | |
| SCHEMBL7838766 | 0.77 | MMP3 (0.37) | MMP1MMP3MMP9MAPTMEN1 | |
| SCHEMBL7955756 | 0.77 | ALDH1A1 (0.36) | MMP1MMP3MMP9MAPTMEN1 | |
| SCHEMBL7955753 | 0.77 | ALDH1A1 (0.36) | MMP1MMP3MMP9MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137640-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000035885-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |