SCHEMBL7855259

SCHEMBL7855259

O=C(NC1CCCCC1)C(=O)C1CCCN1C(=O)c1ccc(CN2CCCCC2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.52
RAB9A P51151 1/20 0.52
KMT2A Q03164 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
MMP2 P08253 2/20 0.50
MMP9 P14780 2/20 0.50
MMP8 P22894 2/20 0.50
MMP13 P45452 2/20 0.50
KDM4E B2RXH2 1/20 0.50
HTR1A P08908 2/20 0.46
HTR7 P34969 2/20 0.46
HRH3 Q9Y5N1 4/20 0.46
HDAC1 Q13547 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
MBTD1 Q05BQ5 1/20 0.44
L3MBTL3 Q96JM7 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
FAP Q12884 1/20 0.44
DPP7 Q9UHL4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7844467 0.92 NPC1 (0.65) NPC1RAB9AKMT2ASMN1; SMN2MMP2
SCHEMBL9564104 0.83 EPHX2 (0.53) NPC1RAB9AKDM4EFAP
SCHEMBL7852978 0.79 SMN1; SMN2 (0.50) NPC1RAB9AKMT2ASMN1; SMN2MMP2
SCHEMBL7843881 0.77 FAP (0.46) NPC1RAB9AKDM4EFAP
SCHEMBL7855232 0.77 FAP (0.46) NPC1RAB9AKDM4EFAP
Hydrochloric Acid SCHEMBL7856176 0.74 NPC1 (0.56) NPC1RAB9AKMT2ASMN1; SMN2KDM4E
SCHEMBL7853236 0.72 PKM (0.60) NPC1KDM4E
SCHEMBL7853929 0.72 NPC1 (0.62) NPC1RAB9AKMT2ASMN1; SMN2MMP2
SCHEMBL7843748 0.71 EPHX2 (0.60) KDM4EL3MBTL1FAP
SCHEMBL7845417 0.69 FAP (0.49) NPC1RAB9AKMT2ASMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0709373-B1 PYRROLIDINE DERIVATIVE ZAIDAN HOJIN BISEIBUTSU (JP) 2001-10-17 EP disclosed
US-5965556-A KETO-ACID AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS FOR INHIBITING THE ACTIVITY OF SERINE PROTEASE OR THIOL PROTEASE BY ADMINISTERING THE DERIVATIVE TO A MAMMAL; ALZHEIMER'S DISEASE ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) 1999-10-12 US disclosed
US-5756763-A ENZYME INHIBITOR ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) 1998-05-26 US disclosed
EP-0709373-A1 NOVEL PYRROLIDINE DERIVATIVE ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) 1996-05-01 EP disclosed