Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL7855880

C1CCOOC1.N.O

nearest known ligand 0.00

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Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Ammonia Solution, Strong. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL8587303 0.95 ALDH1A1 (0.42)
Water SCHEMBL3706340 0.95
Ammonia Solution, Strong SCHEMBL4884987 0.95
Ammonia Solution, Strong SCHEMBL28215682 0.90
SCHEMBL285 0.89
SCHEMBL18185998 0.89 ALDH1A1 (0.46)
SCHEMBL5084531 0.89
Fluoride SCHEMBL9698194 0.89
SCHEMBL145743 0.89
Hydrazine SCHEMBL20766052 0.86

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115843299-A Synthesis of oligonucleotides and related compounds 詹森生物制药有限公司 2023-03-24 CN disclosed
US-9718815-B2 Heterocyclic compounds and uses thereof INFINITY PHARMACEUTICALS, INC. (US) 2017-08-01 US disclosed
US-20150126506-A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF INFINITY PHARMACEUTICALS, INC. 2015-05-07 US disclosed
US-6300486-B1 CONDENSING A NUCLEOSIDE HAVING ONE HYDROXYL END BEARING A H-PHOSPHONATE GROUP AND THE OTHER PROTECTED WITH POLYMER-BOUND NUCLEOSIDE HAVING FREE HYDROXYL END IN SOLVENT WHICH SWELLS POLYMER, DEPROTECTING, REPEATING, OXIDATION ISIS PHARMACEUTICALS, INC. 2001-10-09 US disclosed
US-5830881-A L-2'3',dideoxy nucleoside analogs as anti-hepatitus B (HBV) agents YALE UNIVERSITY (US) 1998-11-03 US disclosed
US-5631239-A VIRICIDES FOR HEPATITIS YALE UNIVERSITY (US) 1997-05-20 US disclosed
US-5627160-A L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents YALE UNIVERSITY (US) 1997-05-06 US disclosed
US-5561120-A LOW TOXICITY TO HOST CELLS YALE UNIVERSITY (US) 1996-10-01 US disclosed
EP-0707481-A4 1996-05-29 EP disclosed
EP-0707481-A1 L-2',3'-DIDEOXY NUCLEOSIDE ANALOGS AS ANTI-HEPATITIS B (HBV) AND ANTI-HIV AGENTS YALE UNIVERSITY (US) 1996-04-24 EP disclosed
WO-1994027616-A1 L-2',3'-DIDEOXY NUCLEOSIDE ANALOGS AS ANTI-HEPATITIS B (HBV) AND ANTI-HIV AGENTS YALE UNIVERSITY (US) 1994-12-08 WO disclosed
WO-1993017035-A1 2'ISODIDEOXY-β-D-NUCLEOSIDES AS STABLE ANTIVIRAL AGENTS UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1993-09-02 WO disclosed
US-5231174-A 2'isodideoxy-β-D-nucleosides as stable antiviral agents UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1993-07-27 US disclosed
US-5204455-A Monomethoxytrityl protected oligonucleotides bound to a solid support ISIS PHARMACEUTICALS, INC. 1993-04-20 US disclosed
US-5164491-A Large scale synthesis of oligonucleotides and their associated analogs GILEAD SCIENCES (US) 1992-11-17 US disclosed
EP-0361831-B1 ANTIVIRAL NUCLEOSIDE COMBINATION THE WELLCOME FOUNDATION LIMITED (GB) 1992-01-22 EP disclosed
EP-0361831-A1 Antiviral nucleoside combination THE WELLCOME FOUNDATION LIMITED (GB) 1990-04-04 EP disclosed
EP-0163405-A2 Method of rate enhancement for triester synthesis of oligonucleotides using a catalytic alcohol, and compounds for use therein GENENTECH, INC. (US) 1985-12-04 EP disclosed