Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 18/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CHKB | Q9Y259 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7758128 | 0.86 | CHKA (0.49) | CHKAKDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL7851786 | 0.81 | ACHE (0.46) | CHKAALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL28524885 | 0.78 | NPC1 (0.46) | CHKAKDM4EALDH1A1MAPTHPGD | |
| Hydrochloric Acid SCHEMBL7861856 | 0.78 | MEN1 (0.59) | KDM4EALDH1A1MAPT | |
| Bromide SCHEMBL7857771 | 0.75 | MEN1 (0.56) | KDM4EALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL31429413 | 0.69 | NPC1 (0.36) | CHKAALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL9347095 | 0.68 | KDM4A (0.46) | KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL15625753 | 0.68 | BCHE (0.63) | KDM4EALDH1A1MAPTHPGDALOX12 | |
| Iodide SCHEMBL30742767 | 0.68 | KDM4E (0.48) | CHKAKDM4EALDH1A1MAPTHPGD | |
| Hydrochloric Acid SCHEMBL4743545 | 0.67 | CHKA (0.53) | CHKAKDM4EALDH1A1CHKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6204386-B1 | PYRIDINIUM COMPOUND | ARTEVA NORTH AMERICA S.A.R.L. (CH) | 2001-03-20 | — | — | US | claimed |
| US-6204386-B1 | PYRIDINIUM COMPOUND | ARTEVA NORTH AMERICA S.A.R.L. (CH) | 2001-03-20 | — | — | US | disclosed |