Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.59 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7857771 | 0.97 | MEN1 (0.56) | MEN1KMT2APOLBAPOBEC3AAPOBEC3G | |
| Hydrochloric Acid SCHEMBL7758128 | 0.80 | CHKA (0.49) | KDM4EALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL10188095 | 0.80 | POLB (0.61) | MEN1KMT2APOLBAPOBEC3AAPOBEC3G | |
| Bromide SCHEMBL1827960 | 0.78 | POLB (0.59) | MEN1KMT2APOLBAPOBEC3AAPOBEC3G | |
| Hydrochloric Acid SCHEMBL7858178 | 0.78 | CHKA (0.44) | MAPTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7851786 | 0.75 | ACHE (0.46) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL8735025 | 0.73 | MEN1 (0.57) | MEN1KMT2APOLBAPOBEC3AAPOBEC3G | |
| Hydrochloric Acid SCHEMBL11134565 | 0.72 | ALDH1A1 (0.74) | MEN1KMT2APOLBAPOBEC3AAPOBEC3G | |
| Bromide SCHEMBL8664128 | 0.72 | ALDH1A1 (0.60) | MEN1KMT2APOLBAPOBEC3AAPOBEC3G | |
| SCHEMBL8733830 | 0.71 | ALDH1A1 (0.71) | MEN1KMT2APOLBAPOBEC3AAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6204386-B1 | PYRIDINIUM COMPOUND | ARTEVA NORTH AMERICA S.A.R.L. (CH) | 2001-03-20 | — | — | US | claimed |
| US-6204386-B1 | PYRIDINIUM COMPOUND | ARTEVA NORTH AMERICA S.A.R.L. (CH) | 2001-03-20 | — | — | US | disclosed |