Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.39 |
| ▸ | CHKA | P35790 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7858178 | 0.86 | CHKA (0.44) | CHKAALDH1A1KDM4EHPGD | |
| Hydrochloric Acid SCHEMBL7851786 | 0.84 | ACHE (0.46) | CHKAALDH1A1LMNAHTTCYP2D6 | |
| Hydrochloric Acid SCHEMBL7861856 | 0.80 | MEN1 (0.59) | ALDH1A1LMNASMN1; SMN2CYP2C19KDM4E | |
| Bromide SCHEMBL7857771 | 0.77 | MEN1 (0.56) | ALDH1A1LMNAHTTSMN1; SMN2CYP2C19 | |
| Hydrochloric Acid SCHEMBL637319 | 0.75 | RAB9A (0.52) | CHKAALDH1A1LMNAHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL29754142 | 0.75 | RAB9A (0.52) | CHKAALDH1A1LMNAHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL31429413 | 0.74 | NPC1 (0.36) | CHKAALDH1A1LMNAHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9347095 | 0.73 | KDM4A (0.46) | ALDH1A1LMNAHTTSMN1; SMN2CYP2D6 | |
| SCHEMBL2469671 | 0.72 | RAB9A (0.53) | CHKAALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL29519716 | 0.72 | RAB9A (0.53) | CHKAALDH1A1LMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001085825-A2 | METHOD OF POLYCARBONATE PREPARATION | GENERAL ELECTRIC COMPANY (US) | 2001-11-15 | — | — | WO | disclosed |
| US-6204386-B1 | PYRIDINIUM COMPOUND | ARTEVA NORTH AMERICA S.A.R.L. (CH) | 2001-03-20 | — | — | US | disclosed |