SCHEMBL7858660

SCHEMBL7858660

C=Cc1ccc([SiH2]OC(=O)C(C)C)cc1

nearest known ligand 0.40

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TAS1R3 Q7RTX0 2/20 0.40
TAS1R1 Q7RTX1 2/20 0.40
MIF P14174 1/20 0.38
ALDH1A1 P00352 1/20 0.37
TDP1 Q9NUW8 1/20 0.34
ELANE P08246 1/20 0.32
CHRNB2 P17787 1/20 0.31
CHRNB4 P30926 1/20 0.31
CHRNA3 P32297 1/20 0.31
CHRNA7 P36544 1/20 0.31
CHRNA4 P43681 1/20 0.31
TRPA1 O75762 1/20 0.31
SLC6A2 P23975 1/20 0.31
SLC6A4 P31645 1/20 0.31
SLC6A3 Q01959 1/20 0.31
PTGS2 P35354 1/20 0.31
FGFR1 P11362 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL706769 0.86 ELANE (0.39) MIFALDH1A1ELANE
SCHEMBL7858566 0.81 PTGS2 (0.42) TAS1R3TAS1R1MIFTDP1TRPA1
SCHEMBL1053847 0.77 ELANE (0.43) ALDH1A1TDP1ELANE
SCHEMBL21522357 0.75 ELANE (0.51) ALDH1A1ELANESLC6A2SLC6A3
SCHEMBL8760384 0.74 ALDH1A1 (0.46) TAS1R3TAS1R1ALDH1A1TDP1CHRNB2
SCHEMBL7079093 0.74 ELANE (0.59) TAS1R3TAS1R1MIFALDH1A1TDP1
SCHEMBL705707 0.71
SCHEMBL2207653 0.70 ALDH1A1 (0.50) TAS1R3TAS1R1ALDH1A1TDP1CHRNB2
SCHEMBL21534572 0.68 ELANE (0.43) TAS1R3TAS1R1ALDH1A1TDP1ELANE
SCHEMBL123173 0.68

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6307081-B1 MACROMONOMER HAS ONE OR MORE SILICON-BONDED HYDROGEN ATOMS AT ONE MOLECULAR CHAIN TERMINAL, AND ONE OR MORE ALIPHATICALLY UNSATURATED SILICON-BONDED ORGANIC GROUPS AT THE OTHER MOLECULAR CHAIN TERMINAL. DOW CORNING SILICONE COMPANY, LTD. (JP) 2001-10-23 US disclosed