Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.36 |
| ▸ | DRD3 | P35462 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 5/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7867529 | 0.85 | CHRNA7 (0.38) | KDM4ELMNAALOX15PARP1 | |
| Cadaverine Tartrate SCHEMBL7866256 | 0.73 | HTR1F (0.35) | DRD2DRD3KDM4ELMNAALOX15 | |
| Oxalic Acid SCHEMBL7870914 | 0.72 | KMT2A (0.45) | KDM4ELMNAALOX15HTR6 | |
| Cadaverine Tartrate SCHEMBL8819052 | 0.71 | HDAC6 (0.48) | — | |
| Oxalic Acid SCHEMBL7865118 | 0.71 | KMT2A (0.45) | KDM4ELMNAALOX15 | |
| Oxalic Acid SCHEMBL7865012 | 0.71 | SLC6A4 (0.40) | DRD2KDM4ELMNAALOX15SLC6A4 | |
| Oxalic Acid SCHEMBL7868026 | 0.70 | CYP19A1 (0.44) | DRD2DRD3SLC6A4HTR6PARP1 | |
| Oxalic Acid SCHEMBL7867561 | 0.69 | HTR1D (0.40) | DRD2KDM4ELMNAALOX15SLC6A4 | |
| Oxalic Acid SCHEMBL7867999 | 0.68 | DRD2 (0.41) | DRD2DRD3KDM4ELMNAALOX15 | |
| SCHEMBL7868005 | 0.66 | HTR6 (0.41) | KDM4ELMNAALOX15SLC6A4HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| WO-1997047302-A1 | INHIBITION OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |