Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR1E | P28566 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78610 | 0.90 | LMNA (0.43) | IDO1LMNAMAPK1HTTPOLB | |
| SCHEMBL16771200 | 0.80 | PNMT (0.55) | IDO1PNMTTAAR1KCNH2SIGMAR1 | |
| SCHEMBL8037422 | 0.77 | GPR84 (0.41) | PNMTTAAR1KCNH2SIGMAR1GPR84 | |
| SCHEMBL78604 | 0.76 | TSHR (0.38) | LMNAMAPK1TSHRALDH1A1MAPT | |
| SCHEMBL15784840 | 0.76 | GPR84 (0.42) | IDO1LMNAMAPK1HTTPNMT | |
| SCHEMBL19398823 | 0.76 | HSPA5 (0.43) | IDO1LMNAMAPK1L3MBTL1PNMT | |
| SCHEMBL12062356 | 0.75 | PNMT (0.46) | IDO1PNMTTAAR1SIGMAR1GPR84 | |
| SCHEMBL12445277 | 0.74 | IDO1 (0.57) | IDO1LMNAMAPK1PNMTTAAR1 | |
| SCHEMBL26074534 | 0.74 | S1PR1 (0.41) | IDO1LMNAMAPK1HTTPYCR1 | |
| SCHEMBL91283 | 0.74 | GPR84 (0.44) | HTTL3MBTL1PNMTTAAR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |