Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78606 | 0.90 | IDO1 (0.39) | LMNAMAPK1HTTPOLBL3MBTL1 | |
| SCHEMBL15716656 | 0.81 | IGF1R (0.53) | IDO1IGF1RALOX15KCNH2TMEM97 | |
| SCHEMBL15784840 | 0.80 | GPR84 (0.42) | LMNAMAPK1HTTGPR84IDO1 | |
| SCHEMBL12062356 | 0.79 | PNMT (0.46) | GPR84IDO1IGF1RALOX15GLA | |
| SCHEMBL8037047 | 0.78 | SKP2 (0.40) | GPR84CYP2C8IGF1RALOX15KDM4E | |
| SCHEMBL91281 | 0.75 | L3MBTL1 (0.43) | L3MBTL1GPR84CYP2C8IGF1RALOX15 | |
| SCHEMBL13154801 | 0.74 | CYP2C8 (0.39) | L3MBTL1CYP2C8IGF1RALOX15REN | |
| SCHEMBL19398823 | 0.73 | HSPA5 (0.43) | LMNAMAPK1L3MBTL1IDO1ALOX15 | |
| SCHEMBL15809160 | 0.72 | MRGPRX4 (0.48) | LMNAPOLBKDM4E | |
| SCHEMBL78902 | 0.72 | LMNA (0.41) | LMNAMAPK1HTTPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |