Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | SNCA | P37840 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7856431 | 1.00 | HDAC1 (0.45) | HDAC1SNCAPKMHDAC4MEF2D | |
| SCHEMBL7863285 | 0.82 | ITGB3 (0.48) | MAPTPOLBMAPK1ALDH1A1SIRT1 | |
| SCHEMBL7864754 | 0.81 | PTPN11 (0.48) | MAPTPOLBMAPK1ALDH1A1LMNA | |
| SCHEMBL7856433 | 0.81 | ITGB3 (0.54) | MAPTPOLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7856428 | 0.80 | PARP1 (0.44) | PKMMAPTPOLBMAPK1ALDH1A1 | |
| SCHEMBL7863273 | 0.79 | FFAR1 (0.43) | HDAC4MEF2DMAPTPOLBMAPK1 | |
| SCHEMBL7455765 | 0.78 | ITGB3 (0.58) | HDAC1POLBALDH1A1SIRT1MEN1 | |
| SCHEMBL7862046 | 0.77 | ITGB3 (0.45) | PKMMAPTPOLBMEN1KMT2A | |
| SCHEMBL7863151 | 0.77 | KMT2A (0.57) | SIRT1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7864761 | 0.77 | ITGB3 (0.43) | MAPTPOLBCYP2C19MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | claimed |
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | disclosed |