Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SENP1 | Q9P0U3 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SENP5 | Q96HI0 | 2/20 | 0.42 |
| ▸ | SENP2 | Q9HC62 | 2/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7863288 | 0.88 | SIRT2 (0.48) | MAPTLMNAMAPK1SENP1TP53 | |
| SCHEMBL7864771 | 0.87 | MAPT (0.46) | MAPTROCK2LMNASENP1MMP13 | |
| SCHEMBL7856464 | 0.83 | TP53 (0.49) | ROCK2LMNAMAPK1SENP1TP53 | |
| SCHEMBL7864274 | 0.82 | LMNA (0.43) | MAPTLMNAMAPK1SENP1TP53 | |
| SCHEMBL7862019 | 0.82 | LMNA (0.45) | MAPTROCK2LMNAMAPK1SENP1 | |
| SCHEMBL7864172 | 0.82 | TP53 (0.46) | ROCK2LMNAMAPK1SENP1TP53 | |
| SCHEMBL7863196 | 0.81 | MAPT (0.50) | MAPTLMNAMAPK1TP53SIRT2 | |
| SCHEMBL7864169 | 0.80 | F10 (0.48) | MAPTLMNAMAPK1SENP1L3MBTL1 | |
| SCHEMBL4161757 | 0.76 | SENP1 (0.59) | MAPTLMNAMAPK1SENP1SENP5 | |
| SCHEMBL7861969 | 0.76 | MAPK1 (0.52) | MAPTROCK2LMNAMAPK1SENP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | claimed |
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | disclosed |