Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SENP1 | Q9P0U3 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7863288 | 0.91 | SIRT2 (0.48) | LMNATP53MAPTSIRT2MAPK1 | |
| SCHEMBL7864256 | 0.88 | MEN1 (0.41) | LMNAMAPTITGB3HTT | |
| SCHEMBL7864322 | 0.86 | AURKA (0.41) | LMNATP53MAPTSIRT2MAPK1 | |
| SCHEMBL7856464 | 0.84 | TP53 (0.49) | LMNATP53SIRT2MAPK1SENP1 | |
| SCHEMBL7862019 | 0.83 | LMNA (0.45) | LMNATP53MAPTSIRT2MAPK1 | |
| SCHEMBL7864172 | 0.83 | TP53 (0.46) | LMNATP53SIRT2MAPK1SENP1 | |
| SCHEMBL7862015 | 0.82 | MAPT (0.51) | LMNATP53MAPTSIRT2MAPK1 | |
| SCHEMBL7864169 | 0.80 | F10 (0.48) | LMNAMAPTSIRT2MAPK1SENP1 | |
| SCHEMBL7861969 | 0.79 | MAPK1 (0.52) | LMNAMAPTSIRT2MAPK1SENP1 | |
| SCHEMBL7856433 | 0.78 | ITGB3 (0.54) | MAPTSIRT2ITGB3ITGA2BHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | claimed |
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | disclosed |