Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 13/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 12/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | TARS1 | P26639 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7871544 | 0.87 | MCL1 (0.49) | MCL1BCL2L1 | |
| SCHEMBL8868618 | 0.86 | MCL1 (0.51) | MCL1BCL2L1 | |
| SCHEMBL7862722 | 0.78 | NPC1 (0.51) | MCL1BCL2L1LMNASMN1; SMN2 | |
| SCHEMBL9574871 | 0.78 | CACNA1B (0.48) | MCL1GPR119KDM4ELMNAHTT | |
| SCHEMBL8868775 | 0.78 | P4HTM (0.53) | MCL1BCL2L1SMN1; SMN2 | |
| SCHEMBL7869459 | 0.78 | MCL1 (0.52) | MCL1BCL2L1TARS1 | |
| SCHEMBL7871560 | 0.78 | MEN1 (0.41) | MCL1BCL2L1SMN1; SMN2 | |
| SCHEMBL9574705 | 0.78 | CACNA1B (0.46) | MCL1LMNAHTTSMN1; SMN2 | |
| SCHEMBL7867703 | 0.75 | EGFR (0.45) | KDM4ELMNASMN1; SMN2 | |
| SCHEMBL8869095 | 0.75 | ALKBH2 (0.57) | MCL1BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |