Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7862831 | 0.93 | PKM (0.41) | PKMEGFRP4HTMMEN1KMT2A | |
| SCHEMBL7874562 | 0.92 | EGFR (0.43) | EGFRP4HTMATMMEN1KMT2A | |
| SCHEMBL7862740 | 0.91 | ALDH1A1 (0.48) | PKMEGFRP4HTMMEN1KMT2A | |
| SCHEMBL7862852 | 0.90 | PTPN1 (0.47) | PKMMEN1KMT2AALDH1A1CA12 | |
| SCHEMBL7869467 | 0.89 | MEN1 (0.48) | PKMP4HTMMEN1KMT2AKDM4E | |
| SCHEMBL7862839 | 0.88 | SMN1; SMN2 (0.48) | PKMP4HTMALDH1A1KDM4EBDKRB1 | |
| SCHEMBL9574735 | 0.88 | ALDH1A1 (0.52) | PKMMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL9574752 | 0.88 | L3MBTL1 (0.53) | PKMP4HTMMEN1KMT2AALDH1A1 | |
| SCHEMBL7867912 | 0.87 | EGFR (0.47) | EGFRP4HTMMEN1KMT2AALDH1A1 | |
| SCHEMBL7871570 | 0.87 | EGFR (0.45) | EGFRP4HTMKMT2ACA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |