Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874570 | 0.91 | EGFR (0.44) | ALDH1A1KDM4EHPGDPKMHSD17B10 | |
| SCHEMBL7869445 | 0.91 | PKM (0.43) | ALDH1A1KDM4EHPGDPKMEGFR | |
| SCHEMBL7862839 | 0.90 | SMN1; SMN2 (0.48) | ALDH1A1KDM4EPKMHSD17B10P4HTM | |
| SCHEMBL7867912 | 0.89 | EGFR (0.47) | ALDH1A1KDM4EHPGDEGFRP4HTM | |
| SCHEMBL7862831 | 0.89 | PKM (0.41) | ALDH1A1KDM4EPKMEGFRP4HTM | |
| SCHEMBL7870515 | 0.88 | POLB (0.44) | ALDH1A1KDM4EHPGDEGFRP4HTM | |
| SCHEMBL7871609 | 0.87 | P4HTM (0.55) | HPGDEGFRP4HTM | |
| SCHEMBL7869467 | 0.87 | MEN1 (0.48) | KDM4EPKMP4HTMCA1CA2 | |
| SCHEMBL7862852 | 0.87 | PTPN1 (0.47) | ALDH1A1PKMMAPTCA1CA2 | |
| SCHEMBL7871570 | 0.86 | EGFR (0.45) | HPGDEGFRP4HTMCA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |