Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 5/20 | 0.38 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 2/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7863160 | 1.00 | EEF2K (0.41) | EEF2KMAPTHTR6LIMK2GBA1 | |
| SCHEMBL7861775 | 0.88 | EEF2K (0.43) | EEF2KMAPTHTR6GBA1ITGB3 | |
| SCHEMBL7863252 | 0.81 | ITGB3 (0.58) | EEF2KMAPTITGB3ITGAV | |
| SCHEMBL7856528 | 0.81 | MEN1 (0.43) | EEF2KMAPTGBA1ITGB3ITGAV | |
| SCHEMBL7866912 | 0.81 | SMN1; SMN2 (0.41) | EEF2KMAPTGBA1ITGB3ITGAV | |
| SCHEMBL7864756 | 0.80 | CA1 (0.38) | MAPTHTR6GBA1ITGB3ITGAV | |
| SCHEMBL7863080 | 0.80 | ALDH1A1 (0.53) | MAPTITGB3ITGAVSMN1; SMN2 | |
| SCHEMBL7861962 | 0.78 | THRB (0.41) | EEF2KMAPTGBA1ITGB3ITGAV | |
| SCHEMBL7861960 | 0.78 | THRB (0.41) | EEF2KMAPTGBA1ITGB3ITGAV | |
| SCHEMBL7864668 | 0.78 | GAA (0.40) | MAPTHTR6ITGB3ITGAVHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | claimed |
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | disclosed |