SCHEMBL7864103

SCHEMBL7864103

CCOC(=O)C1(C(C#N)N[C@@H](CC)c2ccccc2)CC1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.43
CYP2C19 P33261 2/20 0.43
KCNA3 P22001 1/20 0.40
ALDH1A1 P00352 2/20 0.39
TSHR P16473 2/20 0.39
CYP2C9 P11712 1/20 0.39
OPRM1 P35372 5/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
MMP8 P22894 1/20 0.39
OPRD1 P41143 3/20 0.38
OPRK1 P41145 3/20 0.38
SLC22A1 O15245 1/20 0.38
SLC6A4 P31645 1/20 0.38
ADRA1A P35348 1/20 0.38
KCNH2 Q12809 1/20 0.38
GAA P10253 1/20 0.38
KDM4E B2RXH2 1/20 0.37
LMNA P02545 1/20 0.37
HPGD P15428 1/20 0.37
HSD17B10 Q99714 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7614073 0.88 L3MBTL1 (0.42) CYP3A4CYP2C19KCNA3ALDH1A1TSHR
SCHEMBL7613269 0.88 CYP3A4 (0.40) CYP3A4CYP2C19KCNA3ALDH1A1TSHR
SCHEMBL7614012 0.88 CYP3A4 (0.40) CYP3A4CYP2C19KCNA3ALDH1A1TSHR
SCHEMBL7611749 0.88 CYP3A4 (0.40) CYP3A4CYP2C19KCNA3ALDH1A1TSHR
SCHEMBL7619724 0.88 CYP3A4 (0.40) CYP3A4CYP2C19KCNA3ALDH1A1TSHR
SCHEMBL7614988 0.88 CYP3A4 (0.40) CYP3A4CYP2C19KCNA3ALDH1A1TSHR
SCHEMBL7862909 0.80 PPID (0.43) CYP3A4CYP2C19KCNA3ALDH1A1CYP2C9
SCHEMBL7957020 0.77 OPRM1 (0.38) KCNA3OPRM1SMN1; SMN2OPRD1OPRK1
SCHEMBL7612508 0.76 LTC4S (0.43) ALDH1A1GAALMNAHPGD
SCHEMBL5682210 0.75 KCNA3 (0.49) CYP3A4CYP2C19KCNA3ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1148047-A2 Processes for preparing cyclic compounds DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2001-10-24 EP disclosed
US-6218548-B1 (TRIARYLMETHYL)AMINOSPIROPYRROLES DAIICHI PAHARMACEUTICAL CO., LTD. (JP) 2001-04-17 US disclosed
US-6013806-A ANTIBACTEIRAL DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2000-01-11 US disclosed
EP-0829473-A1 PROCESSES FOR PREPARING CYCLIC COMPOUNDS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1998-03-18 EP disclosed